Structure and function of erabutoxins and related neurotoxins from sea snakes and cobras.
نویسندگان
چکیده
This raises the possibility that the processing mechanisms may differ in different tissues. Since bovine /.-endorphin appears to have the same primary structure as rat /.-endorphin (Rubinstein et al., 1977; Li et al., 1977), it is anticipated that the four peptides isolated from ox pituitary, described here, will prove valuable as ‘marker’ peptides in studies on the distribution of /.-endorphin in regions of rat pituitary and brain. Bradbury, A. F., Smyth, D. G. & Snell, C. R. (1975) in Peptides: Structure and Biological Activity (Walter, R. & Meienhofer, J.. eds.), pp. 609-6 I5 Ann Arbor Sci., Ann Arbor, MI Bradbury, A. F., Smyth, D. G., Snell, C. R., Birdsall, N. J. M. & Hulme, E. C. (1 976a) Nature (London) 260,625-626 Bradbury, A. F., Feldberg, W. S., Smyth, D. G. & Snell, C. R. (19766) in Opiates and Endogenous Opioid Peptides (Kosterlitz, H. W., ed.). pp. 9-17, North-Holland, Amsterdam Deakin, J. F. W., Dostrovsky, J. 0. & Smyth, D. G. (1980) Biochem. J.
منابع مشابه
Title Studies on sea snake venom
Erabutoxins a and b are neurotoxins isolated from venom of a sea snake Laticauda semifasciata (erabu-umihebi). Amino acid sequences of the toxins indicated that the toxins are members of a superfamily consisting of short and long neurotoxins and cytotoxins found in sea snakes and terrestrial snakes. The short neurotoxins to which erabutoxins belong act by blocking the nicotinic acetylcholine re...
متن کاملReview Studies on sea snake venom
Erabutoxins a and b are neurotoxins isolated from venom of a sea snake Laticauda semifasciata (erabu-umihebi). Amino acid sequences of the toxins indicated that the toxins are members of a superfamily consisting of short and long neurotoxins and cytotoxins found in sea snakes and terrestrial snakes. The short neurotoxins to which erabutoxins belong act by blocking the nicotinic acetylcholine re...
متن کاملStudies on sea snake venom
Erabutoxins a and b are neurotoxins isolated from venom of a sea snake Laticauda semifasciata (erabu-umihebi). Amino acid sequences of the toxins indicated that the toxins are members of a superfamily consisting of short and long neurotoxins and cytotoxins found in sea snakes and terrestrial snakes. The short neurotoxins to which erabutoxins belong act by blocking the nicotinic acetylcholine re...
متن کاملComparison of Sea Snake (Hydrophiidae) Neurotoxin to Cobra (Naja) Neurotoxin
Both sea snakes and cobras have venoms containing postsynaptic neurotoxins. Comparison of the primary structures indicates many similarities, especially the positions of the four disulfide bonds. However, detailed examination reveals differences in several amino acid residues. Amino acid sequences of sea snake neurotoxins were determined, and then compared to cobra neurotoxins by computer model...
متن کاملThree-dimensional structure of neurotoxin a from venom of the Philippines sea snake.
The crystal structure of neurotoxin a from the venom of Philippines sea snake Laticauda semifasciata has been determined at 2.5 A resolution by x-ray diffraction. Comparison with the structure of neurotoxin b from the same source indicates that the two toxins differ only by substitution at His 26. Earlier chemical work had suggested a difference in chain length and considerable differences in a...
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عنوان ژورنال:
- Biochemical Society transactions
دوره 8 6 شماره
صفحات -
تاریخ انتشار 1980